Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary
نویسندگان
چکیده
منابع مشابه
Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein.
Mutations in grauzone or cortex cause abnormal arrest in Drosophila female meiosis. We cloned grauzone and identified it as a C2H2-type zinc finger transcription factor. The grauzone transcript is present in ovaries and at later developmental stages. A Grauzone-GFP fusion protein is functional and localizes to nuclei of both nurse cells and follicle cells during oogenesis. Three lines of eviden...
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متن کاملThe zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.
About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD(G...
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ژورنال
عنوان ژورنال: Genetics
سال: 2019
ISSN: 1943-2631
DOI: 10.1534/genetics.119.302590